The woman driver, from Sandbach, was killed after her car was in a collision with a bus on the A536 Congleton Road, about half a mile south of the Harrington Arms Pub.
A female passenger was taken to Macclesfield hospital with shoulder injuries.
The accident happened at about 7.45am on Thursday, October 1, and involved a blue Ford Focus and a bus.
Officers from Cheshire Roads Policing team are appealing for information.
Anyone with information should contact Cheshire Police on 101 quoting incident number 156 of 1 October 2015.